CAGGG Repeats and the Pericentromeric Duplication of the Hominoid Genome

Table 1.

Genomic Distribution of the CAGGG Repeat

Library Name Coverage Positives No. of Est. Copy No. of Pstlbands
 2 cosmid LL02NC02 6.4 33 5 4
10 cosmid LA10NC02 6.4 10 2 1
15 cosmid LA15NCO1 6.5 63 10 3
16 cosmid LA16NC02 5.9 93 16 6
Human BAC RPCI–11 11.8 499 42 32
Human BAC CIT-HSP 3.4 151 44 32
Chimp BAC RPCI-43 3.5 111 32 N.A.
Baboon BAC RPCI-41 3.2 96 18 N.A.

  • A summary of the number of CAGGG-repeat positive genomic clones identified after radioactive colony hybridization of 4 chromosome-specific cosmid libraries (human chromosomes 2, 10, 15 and 16) and four total-genomic BAC libraries (2 human, 1 chimpanzee and 1 baboon). Based on the depth of coverage of each library and the number of clones identified, an estimate of the haploid copy number was calculated for each chromosome and species. The number of distinctPstI restriction fragments hybridizing to a 900 bp CAGGG probe (p196.2.1) after Southern analysis of nylon-transferred panel of human monochromosomal somatic cell hybrid DNA is shown. The analysis generally confirms the non-uniform and multicopy distribution of the repeat element (note: the 900 bp CAGGG repeat fragment does not contain a PstI restriction site).

This Article

  1. Genome Res. 9: 1048-1058

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