Phylogenetic analysis of known and predicted tyrosine kinase receptors of C. elegans bases on tyrosine kinase domain alignment. Proteins constituting monophyletic families (LERF, SERF, and four other RTKs) are indicated by shaded boxes. Symbols indicate the bootstrap value [(●) >500; (▴) >700; (♦) >900; 1000 replicates were done; statistical significance is reached with a value of 700]. The sequence of the human nonreceptor type tyrosine kinase ABL1 (underlined) is used as outgroup. Human sequences are with an asterisk (*), and accession nos. are as follows: ABL1 (X16416); DDR (Q08345); EGFR (P00533); EPHA1 (M18391); FGFR1 (M63888); INSR (M32972); MET(P08581); MUSK (AF006464); PDGFRA (P16234); RET (P07949); RON (X70040); ROR1 (M97675); ROS (M34353); TIE1 (X60957); TRKA (M23102); TYRO3 (P55146); UFO (P30530); VEGFR1 (X51602). A phylogenetic tree including more sequences can be found on our web site (http://olan.marseille.inserm.fr/u119/home.html).
