Table 3.
Pairs of Variant Alleles Observed to Have Suggestively Significant Association with the Severity of Atherosclerosis as Represented by Gensini Scores
| Marker I (background) | Marker 2 (additional variant) | Q1 vs Q5 | |||
| combined gender | females only | ||||
| apoE (3/4, 4/4) | CBS278thr/68-bp I | ▴* | — | ||
| apoCIII (−625)del orapoCIII (−455)C | apoBIle-71 | — | ▾* | ||
| apoCIII3206G | apoB Ile-71 | — | ▾* | ||
| PON192arg | apoBIle-71 | — | ▾* | ||
| PON 192arg | ACE(I/D, D/D) | ▴* | — | ||
| ACE (I/D, D/D) | apoB Ile-71 | — | ▾** | ||
| ATIIR1166C | AGT Thr-235 | — | ▴* | ||
| ATIIR1166C | CBS Thr278/68-bp I | — | ▾* | ||
| AGT 235thr | apoBIle-71 | — | ▾** | ||
| AGT 235thr | ATIIR1166C | — | ▴* | ||
| CBS 278thr/68-bp I | apoCIII (−625)del or apoCIII(−455)C | — | ▴* | ||
| CBS 278thr/68-bp I | apoCIII (−428T)C | — | ▴* | ||
| GPIIIa33pro | ATIIR 1166C | ▴* | ▴* | ||
| fibrinogen(−455)A | apoB Ile-71 | — | ▾* | ||
| ▴ Predisposing: | 3 | 5 | |||
| ▾ Protective: | 0 | 7 | |||
-
For each pair listed, the odds ratio corresponds to the risk associated with carrying a second variant allele (relative to the more frequent allele of Marker 2) within the set of individuals who carried a first variant allele (the background marker). A total of 15 markers were analyzed in this pairwise manner. Both combined-gender and female-only quintiles were evaluated, as described in Methods. (**)P < 0.01; (*) 0.001 ≤ P < 0.05; (—) P > 0.05.
