A High-Resolution Microsatellite Map of the Mouse Genome

  1. Michael Rhodes1,
  2. Richard Straw1,
  3. Supem Fernando1,
  4. Andrew Evans1,
  5. Tregaye Lacey1,
  6. Andrew Dearlove1,
  7. John Greystrong1,
  8. Joanne Walker1,
  9. Paula Watson1,
  10. Paul Weston1,
  11. Maria Kelly1,
  12. Dilip Taylor1,
  13. Keith Gibson1,
  14. Chris Mundy1,
  15. Franck Bourgade2,
  16. Christophe Poirier2,
  17. Dominique Simon2,
  18. Ana Lucia Bueno Brunialti2,
  19. Xavier Montagutelli2,
  20. Jean-Louis Gu′enet2,
  21. Andy Haynes3, and
  22. Steve D.M. Brown3,4,5
  1. 1United Kingdom Human Genome Mapping Project (HGMP) Resource Centre, Hinxton CB10 1RQ, UK; 2Institut Pasteur, Paris, France; 3Medical Research Council Mouse Genome Centre and 4Medical Research Council Mammalian Genetics Unit, Harwell OX11 ORD, UK

Abstract

The European Collaborative Interspecific Backcross (EUCIB) resource was constructed for the purposes of high-resolution genetic mapping of the mouse genome (Breen et al. 1994). The large Mus spretus/C57BL/6 backcross of 982 progeny has a genetic resolution of 0.3 cM at the 95% confidence level (∼500 kb in the mouse genome). We have used the EUCIB mapping resource to develop a genome-wide high-resolution genetic map incorporating 3368 microsatellites. The microsatellites are distributed among 2302 genetically separated bins with 1.46 markers per bin on average. Average bin separation is 0.61 cM. This high-resolution genetic map will aid the construction of a robust physical map of the mouse genome.

Footnotes

  • ↵5 Corresponding author.

  • E-MAIL s.brown{at}har.mrc.ac.uk; FAX 01235 824542.

    • Received August 4, 1997.
    • Accepted February 9, 1998.
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  1. doi: 10.1101/gr.8.5.531 Genome Res. 8: 531-542 Cold Spring Harbor Laboratory Press

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