Figure 3.
Comparison of human IGF-1 (top; PDB entry 3gf1, NMR model 4) with a model of type-α M04D8.3 ILP of C. elegans(bottom; SWISS-PROT entry Q21506). Noteworthy differences between the two proteins are mentioned: The C-like domain present in IGF-1 only (darker), the supplementary disulfide bridge present inC. elegans (arrowhead), and the replacement of one of the IGF-1 disulfide bridges by an interaction of two Tyr in C. elegans (π). Two different views are presented for a better understanding of the differences.
