The Relative Power of Family-Based and Case-Control Designs for Linkage Disequilibrium Studies of Complex Human Diseases I. DNA Pooling

Table 5.

Number of Families Required to Detect Linkage Disequilibrium for Sibships with r Affected Sibs Compared with Two Unrelated Controls Using Pooling

r= 1 r = 2 r = 3 r = 4
Dominant
 p = 0.05 207 66 36 27
 p= 0.20 158 73 51 42
 p = 0.70 2,204 1,158 819 656
Recessive
 p = 0.05 28,820 5,015 1,325 431
 p = 0.20 712 154 55 26
 p = 0.70 160 72 49 39
Multiplic.
 p = 0.05 872 265 121 66
 p = 0.20 300 102 52 32
 p = 0.70 352 152 93 67
Additive
 p = 0.05 502 154 74 45
 p = 0.20 238 90 52 36
 p = 0.70 530 231 141 100

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  1. Genome Res. 8: 1273-1288

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