Table 4.
Number of Families Required to Detect Linkage Disequilibrium for Sibships with r Affected and s Unaffected Sibs, without Parents, Using Pooling
| r= 1 | r = 2 | r = 3 | r = 4 | ||||||
| s = 1 | s = 2 | s = 1 | s = 2 | s = 2 | s = 2 | ||||
| Dominant | |||||||||
| p = 0.05 | 753 | 534 | 355 | 227 | 147 | 126 | |||
| p= 0.20 | 489 | 357 | 376 | 247 | 248 | 296 | |||
| p = 0.70 | 5,719 | 4,317 | 6,490 | 4,357 | 5,638 | 7,860 | |||
| Recessive | |||||||||
| p= 0.05 | 79,556 | 59,234 | 22,031 | 14,555 | 4,810 | 1,883 | |||
| p= 0.20 | 2,022 | 1,498 | 745 | 494 | 237 | 145 | |||
| p= 0.70 | 341 | 271 | 269 | 196 | 206 | 255 | |||
| Multiplic. | |||||||||
| p= 0.05 | 2,811 | 2,032 | 1,535 | 992 | 605 | 405 | |||
| p= 0.20 | 891 | 655 | 547 | 361 | 258 | 209 | |||
| p = 0.70 | 831 | 642 | 689 | 478 | 471 | 515 | |||
| Additive | |||||||||
| p= 0.05 | 1,690 | 1,213 | 885 | 569 | 351 | 253 | |||
| p= 0.20 | 717 | 526 | 483 | 318 | 258 | 239 | |||
| p = 0.70 | 1,292 | 990 | 1,117 | 765 | 760 | 818 | |||
