The Relative Power of Family-Based and Case-Control Designs for Linkage Disequilibrium Studies of Complex Human Diseases I. DNA Pooling

Table 3.

Number of Families Required to Detect Linkage Disequilibrium for Sibships with Parents for Four Genetic Models Using Pooling

r = 1 r = 2 r = 3 r = 4 Parent affected r = 1
Dominant
 p = 0.05 314 98 51 37 186
 p= 0.20 224 117 96 97 205
 p = 0.70 2,913 2,222 2,269 2,607 3,179
Recessive
 p= 0.05 38,909 7,071 1,847 599 36,443
 p = 0.20 972 241 95 52 885
 p = 0.70 199 122 113 127 271
Multiplic.
 p= 0.05 1,251 448 218 123 918
 p = 0.20 417 173 101 71 378
 p = 0.70 451 265 215 202 559
Additive
 p = 0.05 734 252 125 76 497
 p = 0.20 333 152 101 80 302
 p = 0.70 686 411 330 299 816

  • Significance level α = 5 × 10−8; power 1 − β = 0.80.

  • Dominant model: f 2 = f 1 = 4; recessive model: f 2 = 4, f 1 = 1; multiplicative model: f 2 = 4,f 1 = 2; additive model: f 2 = 4, f 1 = 2.5.

  • (r) Number of affected sibs.

This Article

  1. Genome Res. 8: 1273-1288

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