The Relative Power of Family-Based and Case-Control Designs for Linkage Disequilibrium Studies of Complex Human Diseases I. DNA Pooling

Table 2.

Conditional Probability of Mating Type G Given rAffected Children and an Affected Parent

Mating typeG Population frequency Frequency [m (r) ij ] given r-affected children
(2,2) g 22 f 2 r+1 g 22 / K r
(2,1) g 21 f 2[(f 2 + f 1) / 2]r g 21 / K r
(2,0) g 20 f 2 f 1 r g 20 / K r
(1,2) g 12 f 1[(f 2 + f 1) / 2]r g 12 / K r
(1,1) g 11 f 2[(f 2 + 2f 1 + 1) / 4]r g 11 / K r
(1,0) g 10 f 1[(f 1 + 1) / 2]r g 10 / K r
(0,2) g 02 f 1 r g 02 / K r
(0,1) g 01 [(f 1 + 1) / 2]r g 10 / K r
(0,0) g 00 g 00 / K r
  • Kr ‘ is the population prevalence ofr affected children and one affected parent, which equals the sum of all numerators in the third column.

This Article

  1. Genome Res. 8: 1273-1288

Preprint Server