The Relative Power of Family-Based and Case-Control Designs for Linkage Disequilibrium Studies of Complex Human Diseases I. DNA Pooling

Table 1.

Conditional Probability [m (r) ij] of Mating Type G Given r Affected Children

Mating typeG Population frequency Frequency (m (r) ij ) given r-affected children
(2,2) g 22 f r 2 g 22 / Kr
(2,1) g 21 [(f 2 + f 1) / 2]r g 21 / Kr
(2,0) g 20 f r 1 g 20 / Kr
(1,2) g 12 [(f 2 + f 1) / 2]r g 12 / Kr
(1,1) g 11 [(f 2 + 2f 1 + 1) / 4]r g 11 / Kr
(1,0) g 10 [(f 1 + 1) / 2]r g 10 / Kr
(0,2) g 02 f r 1 g 02 / Kr
(0,1) g 01 [(f 1 + 1) / 2]r g 01 / Kr
(0,0) g 00 g 00 / Kr
  • Kr is the population prevalence ofr affected siblings, which equals the sum of all numerators in the third column.

This Article

  1. Genome Res. 8: 1273-1288

Preprint Server