Comparative Sequence Analysis of a Gene-Rich Cluster at Human Chromosome 12p13 and its Syntenic Region in Mouse Chromosome 6

Table 2.

Sequence Conservation of Transcribed and Noncoding Regions

Sum length (transcribed) Sum length (noncoding) Weighted conservation (% transcribed) Weighted conservation (% noncoding)
CD4 1492 2435 71.93 69.60
A 2310 1245 86.89 75.66
B 1648 1347 86.15 69.27
GNB3 1319 846 87.28 69.89
C8 1073 298 77.99 70.76
ISOT 2792 2961 90.49 72.81
TPI 1139 761 81.96 70.80
C9 791 83 87.35 66.41
B7 1117 862 79.84 69.45
ENO-2 1646 1507 88.39 73.40
DRPLA 3853 1621 89.05 73.36
C10 447 70 85.17 74.31
PTPN6 2007 1996 87.31 71.55
BAP 1110 1007 87.66 73.59
C2f 850 252 82.70 70.04
C3f 1343 637 88.88 73.47
 Intergenic regions 7241 74.63
Totals 24,937 25,169 85.90 72.65
  • The gap-free segments (⩾50 bp) showing sequence identity (⩾60%) were extracted from SIM alignments using the modified version of CONSERVED. Based on coordinates of exons, the alignments were divided into transcribed and noncoding regions. ESTs that do not correspond to known gene-specific mRNAs were not included in the calculation for transcribed regions. Because the transcription initiation site for some of the genes in this region is not known, the conserved intergenic noncoding segments were calculated separately. For each gene, a weighted percent identity was calculated by ΣCi Fi/N, where Ci is the length in base pairs of each individual aligned sequence of either transcribed or noncoding sequence, Fi is the percent of identity of the aligned sequence, and N is the total number in base pairs of compared transcribed or noncoding sequence.

This Article

  1. Genome Res. 8: 29-40

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