M. leprae genome map indicating regions discussed in the text. Cosmid clone names (starting with B or L) follow the M. lepraemap (Eiglmeier et al. 1993). Cosmid sequences described here are indicated by yellow boxes (see Table 3, below). Red and blue boxes indicate cosmids sequenced by the Institut Pasteur (IP) and other members of M. leprae World Health Organization (WHO) genome consortium, respectively. Unboxed cosmids are mapped but not sequenced. Eighteen of the cosmids sequenced in this study overlapped to form contigs (eight contigs, averaging 67 kb in size). Most of the gaps remaining between adjacent sequenced cosmids were small, and many could be bridged by long-range PCR.
