Physical map of the megabase region containing the cytokine gene cluster on human chromosome 5q31. The scale on the left is in kilobases. In the middle, YAC clones are represented by the medium-length bars, P1 and PAC clones are represented by the shorter bars. The long bar on the right represents a composite map of the overlapping P1 and PAC (H37) clones in the region. The regions depicted in red have been sequenced and analyzed in this study while the regions depicted in black have not been sequenced and/or analyzed. Known and putative genes are color coded according to the computational method by which they were identified as described in Fig. 2. (Dark blue) Genes that were sequenced previously. Except for Ril, all of the genes that were sequenced previously had also been localized to this region of 5q31. (Light blue) Putative genes identified by homology to known proteins. (Green) Putative genes identified by EST matches. (Purple) Putative genes identified by analysis of GRAIL-predicted exons and verified by expression studies. The genomic regions containing known and putative genes that have protein database matches are indicated by an increase in the width of the composite map bar. The direction of transcription for each gene is indicated by a vertical arrow. Locations of identical EST matches are indicated by the horizontal arrows on the left side of the composite map. The number next to the arrow indicates how many EST matches were found at each location. An arrow without a number represents a single EST match.
