Fine Localization of the Torsion Dystonia Gene (DYT1) on Human Chromosome 9q34: YAC Map and Linkage Disequilibrium

Table 4.

Frequency of Associated Haplotype in Control AJ Chromosomes

Locus Observed no. Frequency
D9S62a D9S62b D9S159 D9S2158 D9S2159 D9S2160 D9S63 D9S2162 ASS control expected
2 8 12 4 4 4 16 4 12 0 0.0 0.0
2 8 12 4 4 4 16 4 0 0.0 0.0
2 8 12 4 4 4 16 2 .007 0.0
8 12 4 4 4 16 2 .007 0.0
12 4 4 4 16 2 .007 .001
12 4 4 4 6 .021 .009
8 12 4 4 4 3 .011 .001
4 4 4 19 , .068 .04
4 4 4 16 7 , .025 .005
4 4 4 16 4 2 .007 .002
16 4 12 0 0.0 .003
4 16 4 12 0 0.0 0.0

  • ↵Expected frequencies calculated by multiplying individual allele frequencies from Table 1 and Risch et al. (1995).

  • ↵Base on 280 phased control chromosomes.

  • ↵These include the same two control chromosomes.

  • ↵ P << 0.001.

  • ↵ P = 0.001.

  • ↵ P < 0.05.

  • ↵This increase in observed number suggests some linkage disequilibrium between these markers.

This Article

  1. Genome Res. 7: 483-494

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