Physical map from markers D9S62a to D9S2163containing the DYT1 gene. Markers (SSR and end clones) used to screen YACs and cosmids are represented by a label at the topof the map and a vertical line. YAC and cosmid clones are drawn to scale under the loci that they contain. YACs are indicated by bold horizontal lines with a corresponding name and size. YAC names preceded by asterisks are CEPH coordinates, and the remaining YACs are from the flow-sorted chromosome 9 library. The thin line in YAC 183D9 indicates a region of deletion. YAC clone lengths were estimated by pulsed-field gel electrophoresis and are in brackets next to the YAC names. Cosmids are indicated by smaller horizontal lines. The cosmids were obtained from a chromosome 9-specific cosmid library generated at Lawrence Livermore National Laboratory and should be preceded by the designation LL09NC01. Cosmids were given the average size of 40 kb. Distances between markers are estimated based on their presence or absence in the clones and the clone lengths. A kilobase scale is shown at thebottom. The minimal region containing the DYT1 gene, as defined by haplotype analysis in the AJ population, is indicated by the bracketed region at the bottom.
