Clone–Contig and STS Maps of the Hereditary Hemochromatosis Region on Human Chromosome 6p21.3–p22

Table 1.

Characterization of Selected STSs in and Around the Multicopy Genome Segment by RH Mapping

Query STS Hits Linked STS lod score Bin
sb36e19-Sp6 14 D6S1558 9.74 19
WI-3111 17 D6S1852 12.01 19
sy950h11-18 12 D6S1558 9.18 19
sp202l10-Sp6 34 D6S1986 3.57 73
sp202l10-Sp6 34 D5S2377 3.18 42
sy950h11-21 37 D6S2031 3.79 59
sy950h11-22 42 D6S2031 4.71 59
D6S1016 L+S 35 D6S414 5.20 57
D6S1016 L 14 D6S1558 7.78 19
D6S1016 S 26 D6S2014 6.98 58
sy950h11-24 47 D6S2014 5.25 58
sy950h11-25 38 D6S2014 8.00 58
sy950h11-26 48 D6S2031 12.12 59
sb55c20-Sp6 41 D6S2031 6.29 59
sb109e23-Sp6 46 D6S2031 10.33 59
sb14m14-T7 34 D6S2014 5.94 58
sy899g1-L 11 D6S1558 4.60 19
sy950h11-16 16 D6S2054 9.74 18
sy950h11-28 11 D6S2054 5.80 18
  • STSs are listed in the same order as in Fig.2.

  • Number of RH samples positive for this STS. Ambiguous hits were counted as 0.5. Values >30 are aligned at the right.The total number of RH samples tested was 83.

  • Only the STS with the highest lod score is shown.

  • Numbers refer to the bin numbers on the Stanford Human Genome Center RH maps for chromosomes 6 and 5, v. 1.0. Bin numbers other than 18 and 19 (i.e., outside this region of chromosome 6p21.3–p22) are aligned at the right.

  • Result of two-point analysis with chromosome-5 markers only.

  • L and S denote the large and the small D6S1016 PCR product, respectively. The number of hits for D6S1016 L and D6S1016 S are not additive because five RHs were positive for both STSs.

This Article

  1. Genome Res. 7: 457-470

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