Biological interpretability of scBOND-translated scRNA-seq and scDNAm profiles. (A) KEGG pathway enrichment analysis of DEGs from the original (left) and scBOND-translated (right) scRNA-seq profiles for the Exc_L4-5_FOXP2 cell type in the HumanBrainA data set. (B) GO enrichment results based on DEGs from original (left) and scBOND-translated (right) scRNA-seq profiles. (C) Tissue-specific enrichment analysis of original (left) and scBOND-translated (right) scDNAm profiles for the Inh_CGE_VIP cell type using SNPsea. (D) LDSC-based partitioned heritability analysis comparing enrichment of scBOND-translated scDNAm profiles in four psychiatric disorder-associated traits: depression, schizophrenia, depressed affect, and major depressive disorder (MDD).
