Transcriptomic landscape of transposable elements reveals LTR7-PLAAT4 as a potential oncogene and therapeutic target in pancreatic adenocarcinoma

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Figure 5.
Figure 5.

Oncogenic properties of LTR7-PLAAT4 isoform 2 in pancreatic cancer cell lines. (A) PANC-1 cell proliferation rate comparison using a CCK-8 assay after LTR7-PLAAT4 isoform 2 overexpression. (B,C) PANC-1 cell migration rate comparison using wound healing assay after different PLAAT4 isoforms overexpression. Representative images of the assay were shown at 50× magnification. Scale bar, 200 µm. (D,E) PANC-1 cell migration rate comparison using migration assay after different PLAAT4 isoforms overexpression. Scale bar, 150 µm. (F,G) Invasion assay was used to detect invasion capability after LTR7-PLAAT4 isoform 2 overexpression in PANC-1 cell lines. Scale bar, 150 µm. (H) Secondary mass spectra were obtained from 293T cells overexpressing LTR7-PLAAT4 isoform 2. (I) Phospholipase activity assay of canonical and isoform 2 LTR7-PLAAT4 proteins.

This Article

  1. Published in Advance January 8, 2026, doi: 10.1101/gr.280528.125 Genome Res. 36: 275-290

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