Multi-species analysis of inflammatory response elements reveals ancient and lineage-specific contributions of transposable elements to NF-kB binding

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Figure 4.
Figure 4.

Multiple TF motifs contribute to TE-derived RELA-bound regions across species and cell types. Heat maps of significantly enriched TF motifs from (A) human aortic endothelial cells and (B) bovine aortic endothelial cells. Rows and columns of the heat maps indicate TE subfamilies and TF motifs, respectively. The intensity of heatmaps represent the rank of significantly enriched TF motifs for each TE. (C) RELA motif distribution relative to the consensuses of Bov-tA1, Bov-tA2, and Bov-tA3. Gray and orange represent all instances and RELA-bound instances, respectively.

This Article

  1. Genome Res. 35: 1544-1559

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