Figure 3.
RELA-bound TEs possess active enhancer features for target gene regulation. (A) eRNA signal from ChRO-seq of TeloHAEC around RELA-bound TEs that are distal or proximal to gene TSS with TNF stimulation for 45 min. The cutoff for distal/ proximal elements: 3 kb relative to gene TSS. (B) The distribution of RELA-bound TEs near upregulated, downregulated, and constitutive genes. The three groups of genes were defined using matched RNA-seq data (see Methods). “Background” represents the distribution of all the genomic TEs near the three gene groups, shown in gray. (C) Functional enrichment of RELA-bound TEs by GREAT (McLean et al. 2010).
