Figure 1.
Experimental overview. Comparative epigenomic analysis of the contribution of TEs to NF-kB gene regulatory networks. Primary aortic endothelial cells from human, mouse, and cow were treated with TNF and subjected to ChIP-seq (RELA, H3K4me2, and H3K27ac), ATAC-seq, and RNA-seq. H3K4me3 HiChIP, ChRO-seq, and CRISPR-Cas9 deletions of an exemplar TE-derived region were performed in TeloHAEC. Created in BioRender (https://www.biorender.com).
