Nucleosome binding by TP53, TP63, and TP73 is determined by the composition, accessibility, and helical orientation of their binding sites

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Figure 3.
Figure 3.

Binding site accessibility is a key determinant of TP53 family–nucleosome binding. (A) Measuring library-nucleosome accessibility via MNase digestion, represented by MNase-digestion scores. (Edge) The left or right end of the canonical 146 bp nucleosome core particle. (B–D) Correlating TP53, TP63, or TP73 binding strength with binding-site accessibility (measured by MNase-digestion scores). Shading around regression lines represents 95% confidence intervals.

This Article

  1. Published in Advance February 10, 2025, doi: 10.1101/gr.279541.124 Genome Res. 35: 404-416

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