Ultraviolet damage and repair maps in Drosophila reveal the impact of domain-specific changes in nucleosome repeat length on repair efficiency

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Figure 2.
Figure 2.

Regional differences in chromatin type impact CPD repair activity. (A,B) Relative CPD enrichment (A) and repair activity (30 min; B) binned in 10,000 bp regions across Chromosome 2 of the Drosophila genome. (A) CPD enrichment is normalized to a UV-exposed, naked DNA control. (B) Repair data are normalized to cellular damage data. (C) Chromatin domains superimposed on repair data from B. Data are zoomed in on positions between 5 Mb and the end of Chromosome 2R for increased resolution of bins and exclusion of the centromere-proximal region, which does not have defined domains. Chromatin type was assigned when >50% of the bin was covered by regions assigned to that type. Bins that failed to meet this threshold are colored gray.

This Article

  1. Genome Res. 35: 257-267

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