Aberrant homeodomain–DNA cooperative dimerization underlies distinct developmental defects in two dominant CRX retinopathy models

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Figure 7.
Figure 7.

Monomeric and dimeric K50 HD motifs show different regulatory activity changes in retinal explant MPRAs. (A) Schematics showing explant retinal MPRA experimental pipeline. (B,C) Box and strip plots comparing monomeric (B) or dimeric (C) K50 HD motif activities in explant cultured WT, CrxE80A/+, and CrxE80A/A retinas. (B) CREs overlapped with ATAC-seq peaks that were not significantly reduced in the CrxE80A retinas are plotted. (C) CREs overlapped with ATAC-seq peaks that were significantly reduced in the CrxE80A retinas are plotted. P-values of Mann–Whitney–Wilcoxon tests are annotated.

This Article

  1. Published in Advance December 23, 2024, doi: 10.1101/gr.279340.124 Genome Res. 35: 242-256

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