Aberrant homeodomain–DNA cooperative dimerization underlies distinct developmental defects in two dominant CRX retinopathy models

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Figure 5.
Figure 5.

CrxE80A retinas show defective chromatin remodeling at CREs enriched for dimeric K50 HD motifs. (A) Heatmaps depicting the normalized ATAC-seq or CRX ChIP-seq signal intensities at CrxE80A differentially accessible ATAC-seq peaks. (B,C) PWM logos and enrichment significance E-values of STREME de novo discovered HD motifs under CrxE80A differentially accessible ATAC-seq peaks. (D,E) Line plots showing the average developmental accessibility kinetics of CrxE80A differentially accessible ATAC-seq peaks. The developmental ATAC-seq data are from Aldiri et al. (2017).

This Article

  1. Published in Advance December 23, 2024, doi: 10.1101/gr.279340.124 Genome Res. 35: 242-256

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