Epigenetic drift score captures directional methylation variability and links aging to transcriptional, metabolic, and genetic alterations

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Figure 4.
Figure 4.

Biological and trait enrichments of directional epigenetic drift. This circular plot visualizes Gene Ontology (GO) terms, KEGG pathways, and traits enriched for positive (PosD) and negative (NegD) drift-CpGs. Enrichment score, calculated as −log10(FDR P), increases with distance from center.

This Article

  1. Published in Advance August 1, 2025, doi: 10.1101/gr.280155.124 Genome Res. 35: 2173-2188

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