Chimeric mitochondrial RNA transcripts predict mitochondrial genome deletion mutations in mitochondrial genetic diseases and aging

Table 4.

Chimeric mtRNA frequency in rat muscle samples

Database
Experimental group (n)	Average base pairs sequenced	Chimeric mtRNA FFPM	Mt-co1, 2, 3-Mt-cyb chimeric mtRNA FFPM
Rat aging muscle (PRJNA793055)	2.6 ± 0.17 × 10⁹
18-month control (5)		0.44 ± 0.12^a	0.050 ± 0.035^a
18-month GPA treated (5)		0.55 ± 0.10^a	0.11 ± 0.026^a
34-month control (6)		1.93 ± 0.27^b	0.94 ± 0.13^a
34-month GPA treated (6)		4.20 ± 0.80^c	2.32 ± 0.45^b

(n) Number of rats. Data shown are mean ± SEM. Different superscript letters denote significance at P < 0.05 within the column using pairwise t-test.

Published in Advance November 27, 2024, doi: 10.1101/gr.279072.124 Genome Res. 2025. 35: 55-65

Chimeric mitochondrial RNA transcripts predict mitochondrial genome deletion mutations in mitochondrial genetic diseases and aging