Chimeric mitochondrial RNA transcripts predict mitochondrial genome deletion mutations in mitochondrial genetic diseases and aging

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Figure 7.
Figure 7.

Chimeric mtRNA frequency predicts altered transcription of cellular pathways. (A) Gene set enrichment analysis of differentially expressed genes associated with chimeric mtRNA frequency in rat skeletal muscle aging. Negative correlations of FFPM to gene expression for nuclear-encoded SDHB (B) and COX5b (D) and mitochondrially encoded Mt-co1 (C) and Mt-cyb (E).

This Article

  1. Published in Advance November 27, 2024, doi: 10.1101/gr.279072.124 Genome Res. 35: 55-65

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