Chimeric mitochondrial RNA transcripts predict mitochondrial genome deletion mutations in mitochondrial genetic diseases and aging

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Figure 4.
Figure 4.

Chimeric mtRNAs in aging human brain. (A) Distribution of chimeric mtRNA fusion sites for fusions detected more than seven times in human brain. (B) Location of fusion sites across the human mitochondrial genome and comparison to known mtDNA deletion mutation breakpoint distributions in human brain. (C) Histogram of fusion event sizes in human brain.

This Article

  1. Published in Advance November 27, 2024, doi: 10.1101/gr.279072.124 Genome Res. 35: 55-65

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