Figure 3.
Chimeric mtRNAs in aging human skeletal muscle. (A) PCA plot of human skeletal muscle chimeric mtRNA data. (B) Distribution of chimeric mtRNA breakpoints in 14 younger (left) and 14 older (right) subjects for fusions detected more than seven times. (C) Location of chimeric ends across the human mitochondrial genome and comparison to known deletion breakpoint distributions. Vertical yellow bars denote the location of the human 4977 or common deletion. (D) Histogram of fusion event sizes of chimeric mtRNAs from <30- and >65-year-old subjects.
