Analysis of a cell-free DNA–based cancer screening cohort links fragmentomic profiles, nuclease levels, and plasma DNA concentrations

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Figure 5.
Figure 5.

Deconvolutional analysis of end motifs to deduce the contribution of the six “founder” end motif profiles (F-profile) of plasma DNA fragments within the 231–600 bp size range, among subjects of different cfDNA concentrations. Heatmap analysis was performed, with each row showing the contributions (expressed as z-scores) of each F-profile across subjects with different cfDNA concentrations.

This Article

  1. Published in Advance November 27, 2024, doi: 10.1101/gr.279667.124 Genome Res. 35: 31-42

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