Table 1.
Dosage-sensitivity of human X–Y pair genes across therian mammalian lineages
| X-gene family | Xi expression | Y-gene family | Survival fraction | Branch length (MY) |
|---|---|---|---|---|
| DDX3X | Yes | DDX3Y | 1.00 | 663 |
| KDM6A | Yes | UTY | 1.00 | 663 |
| ZFX | Yes | ZFY | 1.00 | 663 |
| NLGN4X | Yes | NLGN4Y | 1.00 | 140 |
| USP9X | Yes | USP9Y | 0.990 | 656 |
| PRKX | Yes | PRKY | 0.851 | 74 |
| EIF1AX | Yes | EIF1AY | 0.833 | 552 |
| KDM5C | Yes | KDM5D | 0.831 | 687 |
| TXLNG | Yes | TXLNGY | 0.664 | 440 |
| RPS4X | Yes | RPS4Y1 | 0.355 | 343 |
| SOX3 | No | SRY | 1.000 | 967 |
| RBMX | No | RBMY | 0.943 | 912 |
| HSFX1 | No | HSFY1 | 0.834 | 806 |
| TSPYL2 | No | TSPY1 | 0.776 | 642 |
| AMELX | No | AMELY | 0.685 | 454 |
| TBL1X | No | TBL1Y | 0.644 | 90 |
| TMSB4X | No | TMSB4Y | 0.465 | 308 |
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Xi expression is indicated for X-homologs, and survival fraction and branch length are calculated for the corresponding Y-homologs. Genes are sorted first by Xi expression, then by Y-homolog survival fraction, and finally by Y-homolog branch length.
