Post-transcriptional cross- and auto-regulation buffer expression of the human RNA helicases DDX3X and DDX3Y

DDX3X and DDX3Y transcript levels are negatively responsive to Chr Y and Chr X copy numbers, respectively. Scatterplots show DDX3X and DDX3Y transcript levels in cultured fibroblasts with the indicated sex chromosome constitutions. Each point represents a primary fibroblast culture from one individual. (A,B) DDX3Y transcript levels are significantly elevated and DDX3X transcript levels significantly reduced in fibroblasts with multiple Chr Y. (C,D) DDX3X transcript levels are significantly elevated and DDX3Y transcript levels significantly reduced in fibroblasts with multiple Chr X. R-values and statistical significance were calculated using Pearson's correlation.