Post-transcriptional cross- and auto-regulation buffer expression of the human RNA helicases DDX3X and DDX3Y

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Figure 1.
Figure 1.

DDX3X is highly dosage-sensitive and expressed broadly among human tissues. (A) Among human X–Y pair genes, DDX3X ranks highest in combined sensitivity to overexpression (as judged by PCT percentile among all Chr X genes) and diminished function (as judged by LOEUF percentile among all Chr X genes). (B,C) DDX3X (B) and DDX3Y (C) and their chicken ortholog display the highest expression breadth among, respectively, the X and Y members of human X–Y pairs. Note that expression breadth data were not available for the chicken ortholog of KDM5C/D.

This Article

  1. Published in Advance January 10, 2025, doi: 10.1101/gr.279707.124 Genome Res. 35: 20-30

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