Genetic complexity of killer-cell immunoglobulin-like receptor genes in human pangenome assemblies

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Figure 5.
Figure 5.

The discontinuous KIR contigs of HPRC HG002 maternal assembly. The HG002 maternal assembly is segmented into four contigs matching with IPD-KIR alleles, representing an unusual case (one of 94 haplotypes) in the HPRC Year-1 release. No single contig encompasses the entire KIR complex. One contig (4), KIR3DS1-KIR3DP1-KIR2DL4, aligns exclusively between the centromeric and telomeric motifs, suggesting potential structural variations and gene CNVs around the recombinant region.

This Article

  1. Published in Advance September 9, 2024, doi: 10.1101/gr.278358.123 Genome Res. 34: 1211-1223

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