Single-cell analysis reveals transcriptional dynamics in healthy primary parathyroid tissue

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Figure 1.
Figure 1.

Overview of the computational analysis pipeline. (I) Identify parathyroid (PT) cells from scRNA-seq of normal non-human primate samples by high PTH, GCM2, CASR, or CHGA expression. (II) Analyze PTH+ cells and characterize gene trends over pseudotime by gene-based clustering. (III) Identify PT cells from scRNA-seq of hyperfunctioning human PTs. (IV) Map human PT cells to primate manifold with scMMGAN, which generates a representation of human PTH+ cells in the primate space for direct comparison.

This Article

  1. Published in Advance July 8, 2024, doi: 10.1101/gr.278215.123 Genome Res. 34: 837-850

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