A low-abundance class of Dicer-dependent siRNAs produced from a variety of features in C. elegans

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Figure 6.
Figure 6.

Genetic requirements for 22G-RNA formation from 23H-RNA loci. (A–D) Scatter plots display individual 23H-RNA loci as the average log2-geometric mean-normalized 22G-RNA reads in wild-type (x-axis) and mutant (y-axis) animals. (A) mut-14(mg464) smut-1(tm1301). (B) rde-1(ne219). (C) prg-1(n4357). (D) ergo-1(tm1860). All libraries from gravid adults. n = 3 biological replicates for each except mut-14(mg464) smut-1(tm1301) (n = 2). (E) Average log2 ratios of 22G-RNA reads for each of the top 23H-RNA loci (>10 RPM) in the indicated mutants to wild-type. Libraries are the same as in (A–D).

This Article

  1. Published in Advance December 2, 2024, doi: 10.1101/gr.279083.124 Genome Res. 34: 2203-2216

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