Tissue-specific coexpression of host/nested gene pairs. (A) Examples of correlation plots used to calculate Spearman's rank correlation coefficient for the conserved pair Mcph1/Angpt2. (B) Distribution of the Spearman's rank correlation coefficient for all host/nested gene pairs depending on their orientation to each other. (C) Correlation between the Spearman's rank correlation coefficient value and the τ index for all the pairs exhibiting a Spearman's rank correlation coefficient higher than 0.7. (D) Heatmap showing the normalized expression level detected in RNA sequencing data sets for host and nested gene pairs with a Spearman's rank correlation coefficient higher than 0.7. Host genes were clustered using hierarchical clustering according to their expression profile and their nested counterpart were maintained in the same order. The dotted lines are flanking the groups of pairs specifically coexpressed in testis.
