Cover image

Roads represent pathways within the pangenome graph—a unified data structure that captures the rich diversity across multiple genome assemblies. The ggCaller algorithm is represented by robots that navigate these pathways to pinpoint genes or protein-coding sequences, depicted here as ribbons weaving their way along the roads. Each robot's light shines a spotlight on these identified sequences. Multiple robots represent ggCaller's ability to search many pathways at once, making the pinpointing of genes fast. In this issue, the advantage of directly extracting gene sequences from a pangenome graph is demonstrated, and results in substantial improvements in speed and accuracy over algorithms that consider each genome separately. (Cover illustration by Lauren Bell, https://www.laurenbellcreative.com. [For details, see Horsfield et al., pp. 1622–1637.])