Allele-specific RNA N6-methyladenosine modifications reveal functional genetic variants in human tissues

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Figure 6.
Figure 6.

ASm6A analysis reveals m6A-regulating risk variants in common diseases. (A) The fraction of ASm6A variant–associated GWAS risk loci in each tissue (left), and the number of ASm6A variant–associated GWAS risk loci in each sample (right). (B) Enrichment of ASm6As from various tissues in 17 GWAS categories. Fisher's exact test, P < 0.05. (C) Odds ratio showing the enrichment of host gene of ASm6A-associated risk loci from the heart in GWAS traits and diseases. The most significant traits/diseases are shown. (D) Validation of the allelic m6A modifications on GWAS risk variants rs2738464 and rs1131351 by reporter assay.

This Article

  1. Published in Advance September 15, 2023, doi: 10.1101/gr.277704.123 Genome Res. 33: 1369-1380

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