Allele-specific RNA N⁶-methyladenosine modifications reveal functional genetic variants in human tissues

Prediction of trans-factors involved in ASm⁶A regulation. (A) Proportion of the putative functional variants for ASm⁶As that overlap with RNA-related features, including RBP binding sites, RRACH sequence, miRNA target sites, riboSNITCHES variants, and splicing sites. (B) Enrichment of the putative functional variants for ASm⁶As versus random control variants in RRACH sequence and RBP binding sites by Fisher's exact test. (C) Enrichment of the putative functional variants for ASm⁶As in binding sites of different RBPs by Fisher's exact test. (D) Protein–protein interactions between the RBPs in C and known m⁶A writers, readers, and erasers. The red sphere indicates the RBPs in C. (E) Correlation between RBP expression and aggregative m⁶A level of its targets for RBM15 (top) and UPF1 (bottom).