Allele-specific RNA N6-methyladenosine modifications reveal functional genetic variants in human tissues

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Figure 4.
Figure 4.

Validation of putative functional variants for ASm6As by reporter assay. (A) Fraction of validated ASm6As in the reporter assay. ASm6A reporters with different concordance ratios across samples are shown. (B) Correlation of the allelic m6A ratio (REF/total) of validated ASm6A variants in tissue samples and HEK293T reporter assay. The orange dots indicate the functional variants. (C,D) Examples of validated variants. (Left) The relative m6A level of ref versus alt. (Right) Captures showing the overall allelic reads and 15 representative reads.

This Article

  1. Published in Advance September 15, 2023, doi: 10.1101/gr.277704.123 Genome Res. 33: 1369-1380

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