Allele-specific RNA N6-methyladenosine modifications reveal functional genetic variants in human tissues

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Figure 3.
Figure 3.

Prediction of functional variants for ASm6A regulation. (A) Diagram showing the identification strategy of putative functional variants from all ASm6A variants. (B) m6A levels at the reference allele C or alternative allele T of rs1739047003 site in 20 samples. (C) The total proportion (top) and numbers (bottom) of putative functional variants that overlap with annotated functional genetic variants, including eQTL, sQTL, ASE, allele-specific RBP binding (ASB), and GWAS causal variants. The odds ratio, confidence interval, and P-value are shown. (D) Enrichment of putative functional variants in five genetic annotations. The error bars indicate the upper and lower bounds of the 95% confidence interval.

This Article

  1. Genome Res. 33: 1369-1380

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