A Chinese indicine pangenome reveals a wealth of novel structural variants introgressed from other Bos species

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Figure 2.
Figure 2.

Chinese indicine multiassembly graph. (A) Composition of the multiassembly pangenome graph. (B) Variations are stratified by repeat class and by the number of alleles of each variation. The repeat annotation was obtained from the longest allele of each variation. (VNTR) Variable-number tandem repeat, a tandem repeat with the unit motif length ≥7 bp; (STR) short random repeat, a tandem repeat with the unit motif length ≤6 bp; (mixed-inter) a variation involving two or more types of interspersed repeats. (C) Comparing the number and mean size of bubbles present in Brahman-backed pangenome to ARS-UCD1.2-backed pangenome. The number of bubbles is highly consistent, but the size of bubbles is slightly larger on average in ARS-UCD1.2-backed pangenome compared with Brahman-backed pangenome. (D) The genes with alternative complex coding structures because of tandem repeat. Mutation of ALMS1, a large gene with a tandem repeat encoding 47 amino acids. The repeat unit in the VNTR corresponds to a 168- and 60-nucleotide sequence in BDP1 gene and MUC1 gene, respectively.

This Article

  1. Genome Res. 33: 1284-1298

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