CloMu determines mutation fitness, uncovers mutation similarity, and interchangeability, and finds relative causal relationships on a breast cancer cohort (Razavi et al. 2018). (A) CloMu identified eight mutations that have a far greater fitness value than other mutations. (B) Among these eight mutations, five mutations had latent representations with significant nonzero magnitudes. This plot shows that CDH1 and PIK3CA, as well as GATA3 and MAP3K1, are interchangeable on these data. (C) Relative causal relationships between mutation pairs (s, t). A value greater than zero (red) is indicative of mutation s (row) causing mutation t (column) in the same clone, whereas a value smaller than zero (blue) is indicative of mutation s inhibiting the occurrence of mutation t in the same clone.
