Leveraging family data to design Mendelian randomization that is provably robust to population stratification

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Figure 2.
Figure 2.

False-positive rate (FPR) and power comparison between various methods run on simulated data. (A) FPR (y-axis) under varying levels of confounding owing to population stratification (PS), with the x-axis describing the magnitude of the confounding effect of population labels on the exposure and outcome trait. (B) Power (y-axis) as a function of the magnitude of the causal effect of the exposure on the outcome trait (x-axis) in a setting with no confounding. Results are averaged over 1000 simulation replicates.

This Article

  1. Genome Res. 33: 1032-1041

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