Genetic control of the dynamic transcriptional response to immune stimuli and glucocorticoids at single-cell resolution

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Figure 2.
Figure 2.

Identification of differentially expressed genes (DEGs). (A) Heatmap of log2 fold change (LFC) of 6571 DEGs (column) across 16 conditions (four contrasts × four cell types; row). (B) Heatmap of Spearman's correlation of LFC across 16 conditions (four cell types × four contrasts). (C–F) Pathway analysis across cell types and treatment conditions for enrichment in DEG (top) and boxplot for average pathway score (bottom) for four pathways: (C) type I interferon (IFN) signaling, (D) coronavirus disease (COVID-19), (E) glucocorticoid stimulus, and (F) asthma.

This Article

  1. Published in Advance July 13, 2023, doi: 10.1101/gr.276765.122 Genome Res. 33: 839-856

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