Complex hierarchical structures in single-cell genomics data unveiled by deep hyperbolic manifold learning

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 6.
Figure 6.

Embedding of scDHMap on Satpathy's scATAC-seq data. (A) Embedding quality metrics of different methods. (B) scDHMap embedding of Satpathy's scATAC-seq data. (C–F) scDHMap embedding of different cell types. (C) Progenitor cells (cluster 1–9) and myeloid cells (cluster 10–13). (D) Progenitor cells and B cells (cluster 14–16). (E) Progenitor cells and CD4+ T cells (cluster 21–25). (F) Progenitor cells and CD8+ T cells (cluster 26–31). (HSC) Hematopoietic stem cell; (LMPP) lymphoid-primed multipotent progenitor; (CLP) common lymphoid progenitor; (MEP) megakaryocyte–erythroid progenitor; (BMP) basophil–mast cell progenitor.

This Article

  1. Published in Advance February 27, 2023, doi: 10.1101/gr.277068.122 Genome Res. 33: 232-246

Preprint Server



Current Issue

  1. February 2026, 36 (2)
  1. Current Issue
  1. Alert me to new issues of Genome Research