
Conservation of novel genes. Cumulative density plots comparing mean 60-way (A) and six-way (B) exon conservation scores between novel and known single-exon and multiexon genes. Randomized known and novel refer to analyses in which annotations matching exon and intron length were assigned to random positions in the genome. Sixty-way conservation compares all vertebrates, and six-way conservation compares mouse, rat, guinea pig, kangaroo rat, naked mole rat, and squirrel.











