Identifying crossovers and shared genetic material in whole genome sequencing data from families

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Figure 9.
Figure 9.

HMM emission probabilities. Emission probabilities represent the probability of observing a set of family variant calls given that we are in a particular state. To estimate these probabilities, we first use the family inheritance pattern and the inherited variants to calculate the expected genotypes for the family. We then use the error-prone region flag to determine which set of variant calling error rates to use for the state. Finally, we calculate the emission probabilities for the state.

This Article

  1. Published in Advance October 25, 2023, doi: 10.1101/gr.277172.122 Genome Res. 33: 1747-1756

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